Microfluidics Blog Posts
Buoyancy-Driven μPCR for DNA Amplification
DNA is a complex molecule that contains instructions for life and often referred to as a “digital fingerprint” or code telling a cell what to do. DNA is often the only means for accurate testing and identification of biomolecules, cells, or even an entire person during forensic investigations. The need to be able to test for DNA, as quickly as possible, and even at the site where the sample is taken, is becoming more and more important.
Red Blood Cell Separation from a Flow Channel
Before conducting certain blood sample analyses, researchers need to separate the red blood cell particles from the blood plasma. Using lab-on-a-chip (LOC) technology, red blood cell separation can be achieved via magnetophoresis (i.e., motion induced by magnetic fields). Since the magnetic permeability of the particles is different from the blood plasma, their trajectory can be controlled within the flow channel of the LOC device and then separated out from the fluid.
Thermometer Calibration: When Experimentation Falls Short
The International Temperature Scale of 1990 (ITS-90) is the industry calibration standard for measuring temperatures throughout the world. The National Physical Laboratory (NPL) works to establish and maintain the ITS-90 through experiments, most notably, thermometer calibration. To better understand and overcome the shortcomings of the experimental process, Jonathan Pearce, at the UK’s National Physics Laboratory, turned to simulation. His results yielded fascinating results about the microscopic behavior of the liquid-solid interface during the freezing process.
Modeling Electroosmotic Flow and the Electrical Double Layer
Microfluidic devices are so small that the micropumps and micromixers that control and mix the fluid inside the device cannot involve any moving components. Instead, they must take advantage of electroosmotic flow. Here, I will describe the concept of electroosmosis and the electrical double layer (EDL), and how to model these in COMSOL, walking you through two example models.
Modeling an Accurate Drug Delivery Device
There are many different routes through which drugs and other medications can be delivered into a patient’s body during treatment. These include topographical ointments, pills, vaporizers, and injection systems, among others. Many of these drug delivery systems require an enormous amount of precision when it comes to the location, timing, concentration, and amount of the drug to be administered. This is where simulation can be a big help, as it can allow for the modeling of each of these aspects […]
Using a Microfluidic Valve to Separate Charged Particles
When you think of a valve, what is the first thing that comes to mind? Electromagnetic waves, or perhaps, Stokes flow separating charged chemicals in a microchannel system? Maybe neither. The truth is, when researchers try to separate small (in the picoliters region), well-defined sample volumes of chemicals, the dispensing accuracy provided by a mechanical regulator probably won’t suffice. An electrokinetic valve, a type of microfluidic valve, on the other hand, provides the perfect solution by giving researchers the flow […]
Microfluidics Model of an Electroosmotic Micromixer
When you need to mix something at a very small scale you don’t reach for a teeny-tiny whisk. If you’re working with microscale biochemical applications you’d be more likely to rely on diffusion to mix fluids. With highly ordered laminar flow there is no turbulence involved, thus making diffusion a prime candidate for “getting the job done”. But what if you need to mix larger molecules? Larger molecules mean higher molecular weight, which in turn leads to very long equilibration […]
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