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Application ID: 3924

Freeze-drying, or lyophilization, is a process for drying heat-sensitive substances such as foods, blood plasma, and antibiotics. The wet substance is frozen and then, through sublimation, ice (or some other frozen solvent) is removed in the presence of a high vacuum.

This example models the process of ice sublimation in a vial under vacuum-chamber conditions, a test case for many freeze-drying setups.

The model uses the arbitrary Lagrangian-Eulerian (ALE) method to compute the coupled heat and mass balances on a moving mesh attached to the advancing vapor-ice interface.

This model is included as an example in the following products:

Heat Transfer Module

The combination of COMSOL® products required to model your application depends on several factors and may include boundary conditions, material properties, physics interfaces, and part libraries. Particular functionality may be common to several products. To determine the right combination of products for your modeling needs, review the Tabela de Especificações and make use of a free evaluation license. The COMSOL Sales and Support teams are available for answering any questions you may have regarding this.