A Multiphase Porous Medium Transport Model with Distributed Sublimation Front to Simulate Vacuum Freeze Drying
A. Warning, J. M. R. Arquiza, A. K. Datta
Cornell University, Ithaca, NY, USA
A continuum, porous medium formulation with non-equilibrium sublimation was developed and validated for freeze drying without and with uniform microwave volumetric heating. The model incorporates the effect of Knudsen flow at low pressure and low permeability freeze drying. The distributed, non-equilibrium sublimation demonstrated that the sublimation front is a sharp boundary for high ice ...
Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA
We are developing approximations of electrically anisotropic materials for use in novel imaging methods. Our modeling work in COMSOL comprises comparisons of anisotropic and layered models in terms of electrical conductivities measured using different strategies. We tested solution stability in one anisotropic case by varying mesh anisotropy. In our case, good approximations to the true ...
Modeling Arterial Drug Transport From Drug-eluting Stents: Effect of Blood Flow on the Concentration Distribution Close to the Endothelial Surface
F. Bozsak, J.-M. Chomaz, and A. I. Barakat
LadHyX, Ecole Polytechnique
Drug-eluting stents (DES) are commonly used for treating coronary atherosclerosis. Despite the broad effectiveness of DES, ~5% of treated patients experience complications including in-stent restenosis and late-stent thrombosis. Furthermore, drugs used in DES not only inhibit proliferation of smooth muscle cells but also affect re-endothelialization. We have developed a computational model ...
A Study on Nutrient Mass Transport through Porous Channeled Flat Sheet Membrane and Prediction of Maximum Scaffold Thickness for Viable Cell Culture (In-vitro) by 3D Modeling for Tissue Engineering Application
N. M. S. Bettahalli, B. J. Papenburg , D. S. Stamatialis , M. Wessling 
University of Twente, Enschede, The Netherlands & BMS College of Engineering, Bangalore, India
University of Twente, Enschede, The Netherlands
RWTH Aachen University
Tissue engineering (TE) is a multidisciplinary field involving principles of engineering and life sciences to improve the health and quality of life by repairing, restoring, maintaining, or enhancing tissue and organ function using cells, scaffolds, and growth factors alone or in combination. There are several artificial tissues that are already being used which include fabricated skin, ...
I.M. Abdel-Motaleb, J. Lavrencik 
Department of Electrical Engineering, Northern Illinois University, DeKalb, IL, USA
There is urgent need to monitor dental and oral diseases, such as tooth decay, gum diseases, and teeth grinding. Such monitoring can be achieved by embedding sensors in the mouth. This technique faces some difficulties. The first is how the power needed for the operation of the sensors and the associated electronic chips can be generated. This power can be generated using the pressure exerted by ...
R. Sikorski, B. Chapman, T. Merrill
Rowan University, Glassboro, NJ, USA
A CFD cardiac catheter model was developed to determine the potential for blood hemolysis during administration of local therapeutic hypothermia using a CoolGuide catheter. In vivo animal studies have shown that mild hypothermia may reduce reperfusion injury often associated with heart attack. The CoolGuide Catheter System (CCS) delivers rapid local cooling through a cardiac catheter, reducing ...
B. Liu, T. C. Zhu
Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Deformable image registration is a form of medical image processing that can provide insights into the development of phenomenon and variation in normal anatomical structure over time. Prior to post-operative pleural photodynamic therapy (PDT), a series of CT scans of lungs will be acquired. During PDT treatment, an infrared navigation system is used to contour the lungs and provide real-time ...
K. A. Bodnyk, G. J. Noble, N. Fitzpatrick, M. J. Allen, K. Stephenoff, R. T. Hart
Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA
Fitzpatrick Referrals, Godalming, Surrey, United Kingdom
Department of Veterinary Medicine, The Ohio State University, Columbus, OH, USA
The elbow joint in dogs constitutes a complex interaction of three bones, the humerus, radius and ulna. Medial coronoid disease (MCD) is a common cause of lameness in dogs, i.e. fracturing of the most prominent portion of the ulnar joint surface driven in flexion and in pivot against both the humerus and the radius. The cause remains unknown, but prior studies suggest joint incongruency as an ...
李娜 , 李江红 
研究头部损伤机理是对运动撞击中脑损伤进行预测的有效手段。数学模型是分析损伤实验数据、预测人员碰撞损伤程度的唯一方法，但现有的头部损伤有限元模型基于尸体实验数据，且忽略脑组织结构的各向异性。本项目旨在提出并实现一种以损伤生物力学为基础、结合磁共振扫描 DTI 的轴突走向信息的有限元力学模型。提取脑外伤前的弥散张量成像信息，实现深入到轴突水平有限元力学模型的建立，在有限元模拟中采用非线性超弹性力学模型，并植入 NSGAII 最优化方法对有限元模型的材料参数进行优化，从而提高模型的稳定性和计算精度；将计算预测结果与损伤后 DTI 的 FA 值所表现的轴突断裂情况进行验证， 探索活体环境下碰撞损伤中脑轴突的损伤性变化，从而获得脑外伤损伤程度与力学因素之间的关系，为脑外伤损伤程度的预测和脑外伤损伤标准的校正提供精确完整的信息。本项目的研究成果将在汽车碰撞的乘员防护设计上有重要的理论指导价值。 ...
P. Wijdenes , H. Ali , N. Syed , C. Dalton ,
 Centre for Bioengineering Research and Education, University of Calgary, Calgary, AB, Canada
 Department of Electrical and Computer Engineering, Schulich School of Engineering, University of Calgary, Calgary, AB, Canada
 Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada
Our inability to record single cell activity with high resolution over a long period of time precludes fundamental understanding of nervous system functions, both under normal and pathological conditions. While the fabrication of current micro- and nano-electrodes has advanced our capabilities to perform long-term recordings, this has been at the expense of signal resolution due to low sealing ...