Numerical Prediction of Particle Dynamics Within a Cytometer. Application to Counting and Sizing by Impendance Measurement
HORIBA Medical, Montpellier, France
This paper describes how to numerically tackle the problem of counting and sizing particles by impedance measurement in an orifice–electrode system. The model simulate the particle dynamics submitted to strong hydrodynamic stresses through a microorifice and compute the voltage pulses generated by the modification of the inner dielectric medium. This FSI problem is solved on a moving mesh by ...
Priyadarshini Natarajan , Rajkumar ElagiriRamalingam
Division of Biomedical Engineering, School of Biosciences and Technology, VIT University, Tamil Nadu, India
Intracerebral hemorrhage is a condition where a blood vessel in the brain ruptures and causes internal bleeding leading to hemorrhagic stroke. 800 in every 100,000 people suffer from stroke each year and it's one of the major causes of mortality worldwide. Diagnosis involves Neurological examination with MRI/CT scans which is costly and time consuming. Microwave Tomography (MWT) is proposed as a ...
P. Krastev, and B. Tracey
Neurometrix, Inc., Waltham, Massachusetts, USA
Nerve localization is important for applications in regional anesthesia. Localization is achieved by stimulating the nerve with an electric field produced by a current from a needle inserted into the body of the patient, close to the target nerve. Modeling of the electric field in close proximity to the nerve may help to explain observed variations in threshold currents and can help to ...
G. Megali, D. Pellicanò, M. Cacciola, F. Calarco, D. De Carlo, F. Laganà, and F.C. Morabito
DIMET Department, Faculty of Engineering, University “Mediterranea” of Reggio Calabria, Reggio Calabria, Italy
Constitutive properties of living cells are able to withstand physiological environment as well as mechanical stimuli occurring within and outside the body. We examined fluid flow and Neo-Hookean deformation related to the rolling effect. A mechanical model to describe the cellular adhesion with detachment is here proposed. We developed a finite element analysis, simulating blood cells attached ...
Simulation of Chemotractant Gradients in Microfluidic Channels to Study Cell Migration Mechanism in Silico
P. Wallin, E. Bernson, J. Gold
Chalmers University of Technology, Applied Physics, Biological Physics, Gothenburg, Sweden
Cell migration of endothelial cells along gradients is an important process in vivo and an interesting target for cancer therapeutics. Microfluidics offer very powerful tools to study such migration processes in detail in the lab. In this study, we describe a model to simulate molecular gradients in a diffusion based microfluidic gradient generator and how a cell senses these gradients via cell ...
U. Topaloglu, Y. Yan, P. Novak, P. Spring, J. Suen, and G. Shafirstein
 Department of Information Technology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Department of Otolaryngology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Thermal ablation in the head and neck requires accurate thermal dose delivery to target tissue while protecting the structure and function of nearby tissue and organs. In this study, we present a method that allows importing Computed Tomography (CT) scans to COMSOL, in order to model accurately the expected pathological outcomes prior to thermal ablation treatment. Thermal ablation of a virtual ...
J.L. Smart, and M. Kaliszan
University of Kentucky, Paducah, KY, USA
Medical University of Gdansk, Gdansk, Poland
COMSOL Multiphysics® 4.0 was used to study conductive and convective heat transfer from the human eyeball to the surrounding air. Postmortem temperature decay curves were collected in eyeballs of numerous human corpses. Of course, these curves represent only a portion of the complete temperature decay curve, since the pathologist is able to start collecting temperature data only after some ...
A Multiscale-Multiphysics Model for Axon Pathfinding Simulation, the Example of the Olfactory System
G. Naldi, G. Aletti, P. Causin
Dipartimento di Matematica ‘F. Enriques’, Università degli Studi di Milano, Milano, Italy
In the developing embryo, neurons form connections by projecting axons to appropriate target areas. The projection process includes neurite elongation, resulting from the assembly of new cytoskeletal material at the free end of the axon, a complex cascade of steering decisions, driven by biomechanical properties of the surrounding environment and by signals in it. In this work we focus on the ...
A. González-Suárez, M. Trujillo, J. Koruth, A. D'Avila, E. Berjano
Biomedical Synergy, Electronic Engineering Department,Universitat Politècnica de Valencia, Valencia, Spain
Instituto Universitario de Matemática Pura y Aplicada, Universitat Politècnica de Valencia, Valencia, Spain
Helmsley Cardiac Electrophysiology Center, Mt SinaiMedicalCenter and School of Medicine, New York, NY, USA
Previous studies proposed using bipolar radiofrequency ablation across two catheters placed on opposing surfaces of the ventricular wall to create transmural lesions. 2D and 3D models were built and solved with COMSOL Multiphysics software. With these models, it was possible to study the temperature distribution and lesion geometry (Figure), to compare the potential of two ways of applying ...
J.Borana, J.M.Lee, B.G.Chung
Indian Institute of Technology Guwahati, Guwahati, India
Department of Mechanical Engineering, Sogang University, Seoul, Korea
We developed the dual-micropillar-based microfluidic platform to control cellular behavior. The 4×4 dual micro-pillar based platform consists of 16 circular-shaped outer micropillars and 8 saddle shaped inner-micropillars. We simulated various shapes of inner micropillars to analyze the shear stress inside the inner micropillar. Therefore, this dual-micropillar-based microfluidic platform could ...