V. Tidwell, P. LaRosa, M. Zhang, H. Eswaran, A. Nehorai
Department of Electrical & Systems Engineering, Washington University in St. Louis, St. Louis, MO, USA
Monsanto Company, Technology Pipeline Solutions, St. Louis, MO, USA
OB/GYN Department, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Uterine contractions during pregnancy are currently poorly understood – experts disagree on the mechanisms by which contractions propagate through the organ and the structural layout of the uterine muscle fibers. We have developed a multi-scale model of the uterus, at the cellular, tissue, and organ levels. By comparing simulated abdomen-level magnetic field readings from our model to clinical ...
R. Penjweini , T. C. Zhu , M. M. Kim ,
 Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Photofrin-mediated photodynamic therapy (PDT) is used after surgical resection at the University of Pennsylvania to treat the microscopic disease for malignant pleural mesothelioma and to increase survival rate. When Photofrin is exposed to laser light at 630 nm in well-oxygenated tissue, it produces reacted singlet oxygen ([1O2]rx) that kills cancer cells. As [1O2]rx is imperative to PDT ...
FEM Analysis and Optimization of Electro-Stimulating Implants for Bone Regeneration and Prevention of Bacterial Infection
T. Bender , J. Ziebart , T. J. Dauben , B. Kreikemeyer , R. Bader 
 Institute of Medical Microbiology, Virology and Hygiene, Rostock University Medical Center, Rostock, Germany; Research Laboratory for Biomechanics and Implant Technology, Department of Orthopedics, Rostock University Medical Center, Rostock, Germany
 Research Laboratory for Biomechanics and Implant Technology, Department of Orthopedics, Rostock University Medical Center, Rostock, Germany
 Institute of Medical Microbiology, Virology and Hygiene, Rostock University Medical Center, Rostock, Germany
The aim of this study is to investigate the influence of electro-magnetic stimulation on bone regeneration and the effect on bacterial infection. Electro-magnetic stimulation is a promising technique and a powerful tool for the enhancement of bone regeneration. To optimize the amplitude of the electric field and also the magnetic flux density norm a finite element analysis (FEM) simulation was ...
P. Krastev, and B. Tracey
Neurometrix, Inc., Waltham, Massachusetts, USA
Nerve localization is important for applications in regional anesthesia. Localization is achieved by stimulating the nerve with an electric field produced by a current from a needle inserted into the body of the patient, close to the target nerve. Modeling of the electric field in close proximity to the nerve may help to explain observed variations in threshold currents and can help to ...
Passive and Active Deformation Processes of 3D Fibre-Reinforced Caricatures of Cardiovascular Tissues
A. Di Carlo, P. Nardinocchi, T. Svaton, and L. Teresi
Modelling and Simulation Lab, Università Roma Tre, Roma, Italy
Dept. of Structural & Geotechnical Engineering, Università di Roma La Sapienza, Roma, Italy
Dept. of Mathematics, University of West Bohemia, Pilsen, Czech Republic
In this paper, we present a mathematical model of contractile elastic solids meant to simulate various districts of the cardiovascular system, and based on the concepts of active deformation and embedded muscle fibres. Specifically, here we deal with the modeling of the gross mechanics of the Left Ventricle (LV) which is strictly related to its pump function. As is well known, the effectiveness ...
A. Candeo and F. Dughiero
Department Electrical Engineering, University of Padova, Padova, Italy
Radiofrequency Ablation (RFA) represents a valid alternative for treating liver metastases in medically complicated patients. Conventional devices currently operate at 500 kHz, due to good conducting properties of tissues. However, the use of lower frequencies (i.e. 20 kHz) has been recently reported to enhance the treatment effectiveness, due to a more pronounced difference in electrical ...
D. Krapohl, S. Loeffler, A. Moser, and U.G.Hofmann
Institute for Signalprocessing, University of Luebeck, Lübeck, Germany
Institute for Neurology, University of Luebeck, Lübeck, Germany
Department of Information Technology and Media, Mid Sweden University, Sundsvall, Sweden
Deep Brain Stimulation (DBS) has been established as an effective treatment for Parkinson's disease and other movement disorders. The stimulation is currently administered using tetrode-macroelectrodes that target the Subthalamic Nucleus (STN). This often leads to side effects which bias the surrounding areas, e.g. the speech centre. Targeting a specific brain region can better be achieved with ...
A. Chanda, A.R. Choudhury, G. Ray, K. Dasgupta, and D. Nag
Jadavpur University, Kolkata, West Bengal, India
Atherosclerosis in arteries is caused by the formation of stenosis : fatty depositions, on the artery wall. In current medicine, the practice is to observe the maximum percentage occlusion at any arbitrary cross-section and diagnose the patient on that basis, which might not always present the real picture due to non-uniformity of the stenosis thickness. The present work attempts to simulate the ...
B. Liu, T. C. Zhu
Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Deformable image registration is a form of medical image processing that can provide insights into the development of phenomenon and variation in normal anatomical structure over time. Prior to post-operative pleural photodynamic therapy (PDT), a series of CT scans of lungs will be acquired. During PDT treatment, an infrared navigation system is used to contour the lungs and provide real-time ...
Simulation and Experimental Analysis of Drug Release Rates from Magnetic Nanocomposite Spheres - new
L. Saeeednia, H. Mehraein, F. Abedin, K. Cluff, R. Asmatulu
Department of Mechanical Engineering, Wichita State University, Wichita, KS, USA
Department of Bioengineering, Wichita State University, Wichita, KS, USA
Targeted drug delivery systems have been wildly studied in cancer therapy due to the toxicity of most of chemotherapeutic drugs. Nanoparticles can be attached to the small molecules of the drugs and serve as drug carriers to deliver the drug molecules into the area of interest. In this research, polymeric microspheres containing biodegradable poly(D, L-lactide-co-glycolide) (PLGA), magnetic ...