Multiphysics Modeling of Cellular Arrays Using Periodic Minimal Surfaces – A Drug and Gene Delivery Application
J.I. Rey, A.J. Llewellyn, R.J. Connolly, J.P. Jimenez, A.M. Hoff, and R.A. Gilbert
University of South Florida, Tampa, FL, USA
Minimal surfaces are found in nature from crystalline structures to biological nano and micro structures such as biomembranes, and osseous formations in sea urchin. An application to electrically mediated drug and gene delivery is presented. Periodic level surfaces which approximate minimal surfaces are used to generate a geometric representation of tissue. A method to create such structures ...
V. Sharma, S. Narmadha, S.K. Dash, R. Veerasamy, B.K. Nashine, K.K. Rajan, and P. Kalyanasundaram
IGCAR, Kalpakkam, Tamil Nadu, India
Prototype Fast Breeder Reactor (PFBR) is a 500MWe, sodium cooled, pool type, mixed oxide (MOX) fuelled reactor. Sodium flow measurement in various loops of the reactor is of prime importance from the operational and safety aspects. To measure the flow of electrically conducting sodium in large secondary circuit pipes, probe type permanent magnet flowmeters (PTFM) are used. PTFM works on the ...
A. Jain, and A. Garg
BITS Pilani, Goa, India
Bhartiya Vidyapeeth College, New Delhi, India
In this paper we suggest a device which combines the operation of a neuron-MOS and an ISFET. An ISFET is an ion-sensitive field effect transistor used to measure ion concentrations in a solution; when the ion concentration changes, the current through the transistor changes accordingly. A voltage between substrate and the oxide surfaces arises due to an ions sheath. It contains a conventional ...
K. Suresh, B.V.M.P.S. Kumar, U.V. Kumar, M. Umapathy, and G. Uma
National Institute of Technology Tiruchirapalli, Tamil Nadu, India
A proximity DC current sensor using of a piezo sensed and actuated cantilever beam with a permanent magnet mounted at its free end is designed and simulated in COMSOL Multiphysics. The change in resonant frequency of cantilever is a measure of the current through the wire. The sensor is found to be linear with good sensitivity.
F. Loos, and H.-D. Ließ
Universität der Bundeswehr München
The purpose of this work is to investigate the triggering behaviour of safety fuses for mobile on board supply systems. The influence of different materials and shapes of the fuses on the triggering behaviour are analyzed. Furthermore, the simulation results obtained by the use of COMSOL Multiphysics® are compared to experimentally achieved data. For the transient simulation of the heat ...
G. C. Bandlamudi[1,2], C. Siegel, C. Heßke, and A. Heinzel[1,2]
ZBT Duisburg, Duisburg, Germany
University of Duisburg-Essen, Duisburg, Germany
High temperature polymer electrolyte membrane fuel cells (HT PEMFCs) are very promising technologies when used in combined cooling and heating power (CCHP) systems. They are operated at 160°C, offering the possibility of high tolerance to fuel impurities and a possibility to use the heat generated for cooling and heating purposes, leading to higher total system efficiency. Employing a 24 ...
M. Souley, and A. Thoraval
Ecole des Mines
Parc de Saurupt, France
The long-term behaviour of the underground excavations is a social and economic challenge particularly in the contexts of post-mining or radioactive waste storage. Numerical modelings are currently used to understand and forecast the complex behaviour of rock mass around the underground cavities. In order to accurately perform these multiphysics modelings at high space and time scales, it is ...
P.K. Jain, V.B. Khane, J.D. Freels
Oak Ridge National Laboratory, Oak Ridge, TN, USA
Missouri University of Science and Technology, Rolla, MO, USA
Simulation models for steady state thermal hydraulics analyses of ORNL’s HFIR have been developed using COMSOL. A single fuel plate and coolant channel of each type of HFIR fuel element was modeled in three dimensions. The standard k-? turbulence model was used in simulating turbulent flow with conjugate heat transfer. The COMSOL models were developed to be fully parameterized to allow ...
J. Ebert, S. Ghosal, A. Emami-Naeini
SC Solutions, Sunnyvale, CA, USA
This paper describes the development of a COMSOL model of Electro-Chemical-Mechanical Planarization (ECMP) that was validated with experimental data. ECMP is used for processing of semiconductor wafers. We developed a 2D model of flow of phosphoric acid solution (the electrolyte) between two parallel plates that focuses on the physics and electrochemistry in ECMP. The model includes steady-state ...
Lowering of the Interstitial Fluid Pressure as a Result of Tissue Compliance Changes during High Intensity Focused Ultrasound Exposure: Insights from a Numerical Model
E. Sassaroli, B. O'Neill 
The Methodist Hospital Research Institute, Houston, TX, USA
Interstitial fluid pressure (IFP) is elevated in tumors. Owing to this elevated IFP, the interstitial fluid velocity (IFV) is negligible throughout the tumor but significant near the tumor margin. Any therapeutic strategy that can lower IFP will improve drug convection within the tumor and decrease convection of drugs from the tumor margin. High intensity focused ultrasound (HIFU) has been shown ...